Bioactive pyrrole-based compounds with target selectivity
GL Petri, V Spano, R Spatola, R Holl… - European journal of …, 2020 - Elsevier
The discovery of novel synthetic compounds with drug-like properties is an ongoing
challenge in medicinal chemistry. Natural products have inspired the synthesis of …
challenge in medicinal chemistry. Natural products have inspired the synthesis of …
Merging ligand-based and structure-based methods in drug discovery: An overview of combined virtual screening approaches
Virtual screening (VS) is an outstanding cornerstone in the drug discovery pipeline. A variety
of computational approaches, which are generally classified as ligand-based (LB) and …
of computational approaches, which are generally classified as ligand-based (LB) and …
[HTML][HTML] Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections
Background: Highly effective novel treatments need to be developed to suppress emerging
coronavirus (CoV) infections such as COVID-19. The RNA dependent RNA polymerase …
coronavirus (CoV) infections such as COVID-19. The RNA dependent RNA polymerase …
Inside perspective of the synthetic and computational toolbox of JAK inhibitors: Recent updates
The mechanisms of inflammation and cancer are intertwined by complex networks of
signaling pathways. Dysregulations in the Janus kinase/signal transducer and activator of …
signaling pathways. Dysregulations in the Janus kinase/signal transducer and activator of …
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity
F Esposito, FA Ambrosio, R Maleddu, G Costa… - European Journal of …, 2019 - Elsevier
A number of compounds targeting different processes of the Human Immunodeficiency Virus
type 1 (HIV-1) life cycle have been developed in the continuing fight against AIDS. Coumarin …
type 1 (HIV-1) life cycle have been developed in the continuing fight against AIDS. Coumarin …
Medicinal Chemistry Perspectives on the Development of Piperazine-Containing HIV-1 Inhibitors
CA Salubi, HS Abbo, N Jahed, S Titinchi - Bioorganic & Medicinal …, 2024 - Elsevier
The Human immunodeficiency virus (HIV) is the causative agent of acquired
immunodeficiency syndrome (AIDS), one of the most perilous diseases known to …
immunodeficiency syndrome (AIDS), one of the most perilous diseases known to …
A drug repurposing screening reveals a novel epigenetic activity of hydroxychloroquine
Multiple myeloma (MM) is an incurable hematological malignancy driven by several genetic
and epigenetic alterations. The hyperactivation of the Polycomb repressive complex 2 …
and epigenetic alterations. The hyperactivation of the Polycomb repressive complex 2 …
1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity
Despite great efforts have been made in the prevention and therapy of human
immunodeficiency virus (HIV-1) infection, however the difficulty to eradicate latent viral …
immunodeficiency virus (HIV-1) infection, however the difficulty to eradicate latent viral …
Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors
Abstract The management of Human Immunodeficiency Virus type 1 (HIV-1) infection
requires life-long treatment that is associated with chronic toxicity and possible selection of …
requires life-long treatment that is associated with chronic toxicity and possible selection of …
In silico repositioning of cannabigerol as a novel inhibitor of the enoyl acyl carrier protein (ACP) reductase (INHA)
Cannabigerol (CBG) and cannabichromene (CBC) are non-psychoactive cannabinoids that
have raised increasing interest in recent years. These compounds exhibit good tolerability …
have raised increasing interest in recent years. These compounds exhibit good tolerability …