Surgery remains the only potentially curative modality for early-stage non-small cell lung
cancer (NSCLC) patients and tissue availability is made possible. However, a proportion of …

Monoclonal antibodies are widely used for the treatment of cancer, inflammatory and
infectious diseases and other disorders. Most of the marketed antibodies are monospecific …

Squamous cell carcinoma (SCC) is an epithelial malignancy involving many anatomical
sites and is the most common cancer capable of metastatic spread. Development of early …

Determination of the role of insulin-like growth factor (IGF) family components in
carcinogenesis of several human tumors is based on numerous epidemiological and pre …

Metastases are responsible for cancer deaths, but the molecular alterations leading to tumor
progression are unclear. Overexpression of the E2F1 transcription factor is common in high …

The therapies targeting mutations of driver genes in cancer have advanced into clinical trials
for a variety of tumors. In glioblastoma (GBM), epidermal growth factor receptor (EGFR) is …

Trop‐2, a cell surface glycoprotein, contains both extracellular epidermal growth factor‐like
and thyroglobulin type‐1 repeat domains. Low TROP2 expression was observed in lung …

Background The IGF receptor type 1 (IGF-1R) pathway is frequently deregulated in human
tumors and has become a target of interest for anti-cancer therapy. Methodology/Principal …

Preclinical studies in the 1980s defined a role for IGF signaling in the development and
sustainability of the malignant process. Subsequently, antibody, tyrosine kinase, and ligand …

Purpose The purpose of this study was to characterize insulin-like growth factor-1 receptor
(IGF1R) protein expression, mRNA expression, and gene copy number in surgically …