The epidemiology of ALS: a conspiracy of genes, environment and time

A Al-Chalabi, O Hardiman - Nature Reviews Neurology, 2013 - nature.com
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease
of motor neurons, resulting in worsening weakness of voluntary muscles until death from …

Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature

A Chiò, G Logroscino, BJ Traynor, J Collins… - …, 2013 - karger.com
Background: Amyotrophic lateral sclerosis (ALS) is relatively rare, yet the economic and
social burden is substantial. Having accurate incidence and prevalence estimates would …

Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis

B Marin, F Boumédiene, G Logroscino… - International journal …, 2017 - academic.oup.com
Background To assess the worldwide variation of amyotrophic lateral sclerosis (ALS)
incidence, we performed a systematic review and meta-analysis of population-based data …

EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)–revised report of an EFNS task force

EFNS Task Force on Diagnosis and … - European journal of …, 2012 - Wiley Online Library
Background: The evidence base for the diagnosis and management of amyotrophic lateral
sclerosis (ALS) is weak. Objectives: To provide evidence‐based or expert recommendations …

Clinical diagnosis and management of amyotrophic lateral sclerosis

O Hardiman, LH Van Den Berg… - Nature reviews neurology, 2011 - nature.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that results in
progressive loss of bulbar and limb function. Patients typically die from respiratory failure …

Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study

A Chiò, A Calvo, C Moglia, L Mazzini… - Journal of Neurology …, 2011 - jnnp.bmj.com
Background Different amyotrophic lateral sclerosis (ALS) phenotypes have been
recognised, marked by a varying involvement of spinal and bulbar upper and lower motor …

The epidemiology of neuromuscular disorders: a comprehensive overview of the literature

JCW Deenen, CGC Horlings… - Journal of …, 2015 - content.iospress.com
Background: In 1991, the first world survey of neuromuscular disorders (NMDs) was
published in the peer reviewed literature. Since then, diagnostics have been greatly …

The multistep hypothesis of ALS revisited: the role of genetic mutations

A Chiò, L Mazzini, S D'Alfonso, L Corrado, A Canosa… - Neurology, 2018 - AAN Enterprises
Objective Amyotrophic lateral sclerosis (ALS) incidence rates are consistent with the
hypothesis that ALS is a multistep process. We tested the hypothesis that carrying a large …

The genetics and neuropathology of amyotrophic lateral sclerosis

A Al-Chalabi, A Jones, C Troakes, A King… - Acta …, 2012 - Springer
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons
leading to death from respiratory failure within about 3 years of symptom onset. A family …

Effects of gender in amyotrophic lateral sclerosis

PA McCombe, RD Henderson - Gender medicine, 2010 - Elsevier
Background: There is evidence that amyotrophic lateral sclerosis (ALS), also known as
motor neuron disease (MND), is more common in men than in women and that gender …