Metabolic and transcriptomic reprogramming during contact inhibition-induced quiescence is mediated by YAP-dependent and YAP-independent mechanisms
Metabolic rewiring during the proliferation-to-quiescence transition is poorly understood.
Here, using a model of contact inhibition-induced quiescence, we conducted 13C-metabolic …
Here, using a model of contact inhibition-induced quiescence, we conducted 13C-metabolic …
HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells
H Shen, OA Ojo, H Ding, LJ Mullen, C Xing… - Nature …, 2024 - nature.com
Hypoxia is a common feature in various pathophysiological contexts, including tumor
microenvironment, and IFN-γ is instrumental for anti-tumor immunity. HIF1α has long been …
microenvironment, and IFN-γ is instrumental for anti-tumor immunity. HIF1α has long been …
Stable Isotope Tracing Analysis in Cancer Research: Advancements and Challenges in Identifying Dysregulated Cancer Metabolism and Treatment Strategies
Metabolic reprogramming is a hallmark of cancer, driving the development of therapies
targeting cancer metabolism. Stable isotope tracing has emerged as a widely adopted tool …
targeting cancer metabolism. Stable isotope tracing has emerged as a widely adopted tool …
[HTML][HTML] Ala-Cys-Cys-Ala dipeptide dimer alleviates problematic cysteine and cystine levels in media formulations and enhances CHO cell growth and metabolism
Cysteine and cystine are essential amino acids present in mammalian cell cultures. While
contributing to biomass synthesis, recombinant protein production, and antioxidant defense …
contributing to biomass synthesis, recombinant protein production, and antioxidant defense …
Elucidating uptake and metabolic fate of dipeptides in CHO cell cultures using 13C labeling experiments and kinetic modeling
The rapidly growing market of biologics including monoclonal antibodies has stimulated the
need to improve biomanufacturing processes including mammalian host systems such as …
need to improve biomanufacturing processes including mammalian host systems such as …
Cross-feeding of amino acid pathway intermediates is common in co-cultures of auxotrophic Escherichia coli
Amino acid auxotrophy refers to an organism's inability to synthesize one or more amino
acids that are required for cell growth. In microbiome research, co-cultures of amino acid …
acids that are required for cell growth. In microbiome research, co-cultures of amino acid …
Leveraging high-resolution mass spectrometry detection of stable isotopes for metabolomics
JD Gomez - 2024 - search.proquest.com
In recent decades, the use of stable isotopes in metabolomics has fueled groundbreaking
discoveries in metabolism research, enabling the tracking of metabolically active …
discoveries in metabolism research, enabling the tracking of metabolically active …
Leveraging high-resolution mass spectrometry detection of stable isotopes for metabolomics
JD Gomez Castro - 2024 - ir.vanderbilt.edu
In recent decades, the use of stable isotopes in metabolomics has fueled groundbreaking
discoveries in metabolism research, enabling the tracking of metabolically active …
discoveries in metabolism research, enabling the tracking of metabolically active …