Hemodynamic functionality of transfused red blood cells in the microcirculation of blood recipients

G Barshtein, D Arbell, S Yedgar - Frontiers in Physiology, 2018 - frontiersin.org
The primary goal of red blood cell (RBC) transfusion is to supply oxygen to tissues and
organs. However, due to a growing number of studies that have reported negative …

Alteration of red cell aggregability and shape during blood storage

T Hovav, S Yedgar, N Manny, G Barshtein - Transfusion, 1999 - Wiley Online Library
BACKGROUND: Storage of blood units (for 35–42 days, depending on the preservative
solution) has been reported to induce changes (eg, reduction of sialic acid level) in red cells …

Parameters of red blood cell aggregation as correlates of the inflammatory state

RB Ami, G Barshtein, D Zeltser… - American Journal …, 2001 - journals.physiology.org
To identify clinically relevant parameters of red blood cell (RBC) aggregation, we examined
correlations of aggregation parameters with C-reactive protein and fibrinogen in unstable …

Circulatory risk in the transfusion of red blood cells with impaired flow properties induced by storage

G Barshtein, N Manny, S Yedgar - Transfusion medicine reviews, 2011 - Elsevier
Red blood cell (RBC) flow properties (FPs), specifically their deformability, aggregability,
and adherence to endothelial cells, play major roles in blood circulation. Their impairment …

A synergistic effect of albumin and fibrinogen on immunoglobulin-induced red blood cell aggregation

R Ben-Ami, G Barshtein, T Mardi… - American Journal …, 2003 - journals.physiology.org
Therapeutic administration of immunoglobulins (Ig) has the potential to precipitate
thrombotic events. This phenomenon may be explained by red blood cell (RBC) …

Kinetics of linear rouleaux formation studied by visual monitoring of red cell dynamic organization

G Barshtein, D Wajnblum, S Yedgar - Biophysical journal, 2000 - cell.com
Red blood cells (RBCs) in the presence of plasma proteins or other macromolecules may
form aggregates, normally in rouleaux formations, which are dispersed with increasing …

A portable microfluidic system for rapid measurement of the erythrocyte sedimentation rate

Z Isiksacan, O Erel, C Elbuken - Lab on a Chip, 2016 - pubs.rsc.org
The erythrocyte sedimentation rate (ESR) is a frequently used 30 min or 60 min clinical test
for screening of several inflammatory conditions, infections, trauma, and malignant diseases …

Deformability of transfused red blood cells is a potent determinant of transfusion‐induced change in recipient's blood flow

G Barshtein, AR Pries, N Goldschmidt… - …, 2016 - Wiley Online Library
Objective There is a growing concern regarding the risks in the transfusion of PRBC, as
numerous studies have reported negative transfusion outcomes, including reduced blood …

The effect of red blood cell aggregation on velocity and cell-depleted layer characteristics of blood in a bifurcating microchannel

JM Sherwood, J Dusting, E Kaliviotis, S Balabani - Biomicrofluidics, 2012 - pubs.aip.org
Red blood cell (RBC) aggregation is a multifaceted phenomenon, and whether it is
generally beneficial or deleterious remains unclear. In order to better understand its effect on …

Polystyrene nanoparticles activate erythrocyte aggregation and adhesion to endothelial cells

G Barshtein, L Livshits, LD Shvartsman… - Cell biochemistry and …, 2016 - Springer
Nanoparticles (NPs) are drawing an increasing clinical interest because of their potential
use as drug carriers. Recently, a new strategy for elevation of NPs in vivo circulation time …