Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …

Background The retina, as part of the central nervous system (CNS) with limited capacity for
self-reparation and regeneration in mammals, is under cumulative environmental stress due …

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …

Glaucoma is the leading cause of global irreversible blindness, necessitating research for
new, more efficacious treatment options than currently exist. Trabecular meshwork (TM) cells …

Ocular corticosteroids are commonly used clinically. Unfortunately, their administration
frequently leads to ocular hypertension, ie, elevated intraocular pressure (IOP), which, in …

The limbus is a transition from the cornea to conjunctiva and sclera. In human eyes, this thin
strip has a rich variation of tissue structures and composition, typifying a change from scleral …

Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening
adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the …

This study aimed to investigate the protective effect of metformin on trabecular meshwork
(TM) and explore its molecular mechanisms in vivo and in vitro. Ocular hypertension (OHT) …

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a
valuable model system to study the generation and mechanisms modulating conventional …