Zinc complexes with nitrogen donor ligands as anticancer agents

M Porchia, M Pellei, F Del Bello, C Santini - Molecules, 2020 - mdpi.com
The search for anticancer metal-based drugs alternative to platinum derivatives could not
exclude zinc derivatives due to the importance of this metal for the correct functioning of the …

Metal compounds against neglected tropical diseases

YC Ong, S Roy, PC Andrews, G Gasser - Chemical reviews, 2018 - ACS Publications
Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Bioinorganic antimicrobial strategies in the resistance era

A Regiel-Futyra, JM Dąbrowski, O Mazuryk… - Coordination Chemistry …, 2017 - Elsevier
Abstract The emergence of Multi-Drug-Resistant (MDR) organisms has become a major
worldwide clinical problem. The extensive and routine use of the first-line antibiotics to …

Recent advances in drug discovery against Mycobacterium tuberculosis: Metal-based complexes

CB Scarim, RL de Farias, AV de Godoy Netto… - European Journal of …, 2021 - Elsevier
Metal-based drugs are privileged motifs that act as primary pharmacophores in bioactive
compounds for various diseases, including tuberculosis (TB). This potentially life-threatening …

Novel lawsone-containing ruthenium (II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells

RA De Grandis, PWS Dos Santos, KM de Oliveira… - Bioorganic …, 2019 - Elsevier
This study describes a series of newly synthesized phosphine/diimine ruthenium complexes
containing the lawsone as bioligand with enhanced cytotoxicity against different cancer …

Bioactive mixed-ligand zinc (II) complexes with 1H-tetrazole-5-acetic acid and oligopyridine derivatives

EA Ermakova, JA Golubeva, KS Smirnova… - Polyhedron, 2023 - Elsevier
Abstract 1H-tetrazole-5-acetic acid is bifunctional ligand that was employed for the synthesis
of zinc (II) complexes in the presence of secondary ligands such as oligopyridines (dmphen …

A “Golden Age” for the discovery of new antileishmanial agents: current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione …

LB Rosa, RL Aires, LS Oliveira, JV Fontes… - …, 2021 - Wiley Online Library
Leishmaniasis is one of the most neglected diseases worldwide and is considered a serious
public health issue. The current therapeutic options have several disadvantages that make …

Metallodrugs for the treatment of trypanosomatid diseases: Recent advances and new insights

M Navarro, RMS Justo, GYS Delgado… - Current …, 2021 - benthamdirect.com
Trypanosomatid parasites are responsible for many Neglected Tropical Diseases (NTDs).
NTDs are a group of illnesses that prevail in low-income populations, such as in tropical and …

Cytotoxic and apoptotic effects of ternary silver (i) complexes bearing 2-formylpyridine thiosemicarbazones and 1, 10-phenanthroline

DES Silva, AB Becceneri, MC Solcia… - Dalton …, 2020 - pubs.rsc.org
New silver (I) compounds containing 2-formylpyridine-N (4)-R-thiosemicarbazones and 1,
10-phenanthroline (phen) were synthesized and characterized by spectroscopic techniques …

Green synthesis and structural and cytotoxic properties of a new silver (I) complex: Solid-state, single-source precursor of Ag and Ag2O NPs

K Elankathirselvan, P Paunkumar, K Srinivasan… - Journal of Molecular …, 2024 - Elsevier
A new silver complex,[Ag (2-pymc)(NO 3)](Ag-1)[2-pymc= methyl-2-(pyridine-2yl-methylene)
hydrazinecarboxylate], was prepared and subjected to elemental analysis including Fourier …