Intracerebral hemorrhage (ICH) is a highly harmful neurological disorder with high rates of
mortality, disability, and recurrence. However, effective therapies are not currently available …

Twenty-eight kinases found in mammalian genomes share similarity to the budding yeast
kinase Ste20p. This review article examines the biological function of these mammalian …

ATG4B stimulates autophagy by promoting autophagosome formation through reversible
modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase …

The serine/threonine protein phosphatases are targeted to specific subcellular locations and
substrates in part via interactions with a wide variety of regulatory proteins. Understanding …

Genetic screens in Drosophila have revealed that the serine/threonine kinase Hippo (Hpo)
and the scaffold protein Salvador participate in a pathway that controls cell proliferation and …

The Golgi apparatus has long been suggested to be important for directing secretion to
specific sites on the plasma membrane in response to extracellular signaling events …

MST1 is a member of the Sterile-20 family of cytoskeletal, stress, and apoptotic kinases.
MST1 is activated by phosphorylation at previously unidentified sites. This study examines …

Anxiety-associated symptoms following acute stress usually become extinct gradually within
a period of time. However, the mechanisms underlying how individuals cope with stress to …

PDCD10 (programmed cell death 10, TFAR15), a novel protein associated with cell
apoptosis has been recently implicated in mutations associated with Cerebral Cavernous …

Sterile 20 (ste20) protein is an upstream ser/thr kinase in yeast, and several mammalian
Ste20-like (MST) kinases have been identified. This review focuses on the signal …