The realization that autoantibodies can contribute to dysfunction of the brain has brought
about a paradigm shift in neurological diseases over the past decade, offering up important …

GRP78 (glucose-regulated protein of 78 kDa) is traditionally regarded as a major ER
(endoplasmic reticulum) chaperone facilitating protein folding and assembly, protein quality …

In the last few years, immunotherapy has transformed the way we treat solid tumors,
including melanoma, lung, head neck, breast, renal, and bladder cancers. Durable …

Cancer cells adapt to chronic stress in the tumor microenvironment by inducing the
expression of GRP78/BiP, a major endoplasmic reticulum chaperone with Ca2+-binding and …

The sequencing of the human genome and that of numerous pathogens has opened the
door for proteomics by providing a sequence-based framework for mining proteomes. As a …

Disturbance in the folding capacity of the endoplasmic reticulum (ER), caused by a variety of
endogenous and exogenous insults, prompts a cellular stress condition known as ER stress …

Nanomedicines have significant potential for cancer treatment. Although the majority of
nanomedicines currently tested in clinical trials utilize simple, biocompatible liposome …

GRP78, also referred to as BiP, is a central regulator of endoplasmic reticulum (ER) function
due to its roles in protein folding and assembly, targeting misfolded protein for degradation …

Background New biomarkers, such as autoantibody signatures, may improve the early
detection of prostate cancer. Methods With a phage-display library derived from prostate …

Autoantibodies against autologus tumor‐associated antigens have been detected in the
asymptomatic stage of cancer and can thus serve as biomarkers for early cancer diagnosis …