Gram‐positive uropathogens, polymicrobial urinary tract infection, and the emerging microbiota of the urinary tract
Uncomplicated urinary‐tract infection (UTI) is most common in young, sexually active,
nonpregnant, premenopausal women. Gram‐negative bacteria are isolated from 75% to …
nonpregnant, premenopausal women. Gram‐negative bacteria are isolated from 75% to …
[HTML][HTML] The structural biology of Toll-like receptors
I Botos, DM Segal, DR Davies - Structure, 2011 - cell.com
The membrane-bound Toll-like receptors (TLRs) trigger innate immune responses after
recognition of a wide variety of pathogen-derived compounds. Despite the wide range of …
recognition of a wide variety of pathogen-derived compounds. Despite the wide range of …
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling
Cyclic adenosine diphosphate (ADP)–ribose (cADPR) isomers are signaling molecules
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …
Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation
Summary The Toll/interleukin-1 receptor (TIR) domain occurs in animal and plant immune
receptors. In the animal Toll-like receptors, homodimerization of the intracellular TIR domain …
receptors. In the animal Toll-like receptors, homodimerization of the intracellular TIR domain …
Structural biology of the Toll-like receptor family
JY Kang, JO Lee - Annual review of biochemistry, 2011 - annualreviews.org
Innate immune receptors respond to common structural patterns in microbial molecules and
are called pattern recognition receptors. Toll-like receptors (TLRs) play critical roles in the …
are called pattern recognition receptors. Toll-like receptors (TLRs) play critical roles in the …
Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K
TLRs are a family of pattern recognition receptors that recognize conserved molecular
structures/products from a wide variety of microbes. Following recognition of ligands, TLRs …
structures/products from a wide variety of microbes. Following recognition of ligands, TLRs …
Type IV secretion system of Brucella spp. and its effectors
Y Ke, Y Wang, W Li, Z Chen - Frontiers in cellular and infection …, 2015 - frontiersin.org
Brucella spp. are intracellular bacterial pathogens that cause infection in domestic and wild
animals. They are often used as model organisms to study intracellular bacterial infections …
animals. They are often used as model organisms to study intracellular bacterial infections …
Sensing of microbial molecular patterns by Toll‐like receptors
DH Song, JO Lee - Immunological reviews, 2012 - Wiley Online Library
Toll‐like receptors (TLR s) sense structural patterns in microbial molecules and initiate
immune defense mechanisms. The structures of many extracellular and intracellular …
immune defense mechanisms. The structures of many extracellular and intracellular …
Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains
Abstract The Toll/interleukin-1 receptor/resistance protein (TIR) domain is a protein–protein
interaction domain consisting of 125–200 residues, widely distributed in animals, plants and …
interaction domain consisting of 125–200 residues, widely distributed in animals, plants and …
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
Initiation of the innate immune response requires agonist recognition by pathogen-
recognition receptors such as the Toll-like receptors (TLRs). Toll/interleukin-1 receptor (TIR) …
recognition receptors such as the Toll-like receptors (TLRs). Toll/interleukin-1 receptor (TIR) …