Groundbreaking advances in volume electron microscopy and specimen preparation are
enabling the 3-dimensional visualisation of specimens with unprecedented detail, and …

Management guidelines should identify necessary screening for patients with methylmalonic
acidemia and propionic acidemia, and improve anticipatory management of progressive end …

A quiet revolution is under way in technologies used for nanoscale cellular imaging.
Focused ion beams, previously restricted to the materials sciences and semiconductor …

Mitochondria are extremely pleomorphic organelles. Automatically annotating each one
accurately and precisely in any 2D or volume electron microscopy (EM) image is an …

Mapping biological circuit connectivity has revolutionized our understanding of structure-
function relationships. Although connectomic analyses have primarily focused on neural …

The electron microscope has contributed deep insights into biological structure since its
invention nearly 80 years ago. Advances in instrumentation and methodology in recent …

The function of biological cells is intimately associated with their internal organization, in
which multiple subcellular structures have specialized roles. Such subcellular structures …

Technical advances in the ability to measure mitochondrial dysfunction are providing new
insights into mitochondrial disease pathogenesis, along with new tools to objectively …

Simple Summary Mitochondria, which play crucial roles in energy production and in
maintaining cellular homeostasis, are potential therapeutic targets in a variety of diseases …

A fundamental goal in biology is to determine how cellular organization is coupled to
function. To achieve this goal, a better understanding of organelle composition and structure …