With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Lead is a heavy metal pollutant that is widely present in the environment. It affects every
organ system, yet the nervous system appears to be the most sensitive and primary target …

Lead (Pb) can cause neurobehavioral abnormalities. Isochlorogenic acid B (ICAB), a dietary
flavonoid found in tea, sweet potato, artichoke, propolis and several plants, exhibited …

Background: Gestational lead (Pb) exposure can adversely affect offspring health through
multiple mechanisms, including epigenomic alterations via DNA methylation (5mC) and …

Lead (Pb) was implicated in multiple genotoxic, neuroepigenotoxic, and chromosomal‐toxic
mechanisms and interacted with varying synaptic plasticity pathways, likely underpinning …

Highlights•Juvenile developmental Pb exposure impaired rat cognitive ability and induced
apoptotic cell death in hippocampal neurons.•Pb-induced apoptosis in hippocampal …

The placenta performs essential biologic functions for fetal development throughout
pregnancy. Placental dysfunction is at the root of multiple adverse birth outcomes such as …

Upon chronic stress, a fraction of individuals shows stress resilience, which can prevent long-
term mental dysfunction. The underlying molecular mechanisms are complex and have not …

The mode of action (MOA) framework is proposed to inform a biological link between
chemical exposures and adverse health effects. Despite a significant increase in knowledge …

Alzheimer's disease (AD) is a common neurodegenerative disease that is associated with
multiple environmental risk factors, including heavy metals. Lead (Pb) is a heavy metal …