Protein interactions define the homeostatic state of the cell. Our ability to understand these
interactions and their role in both health and disease is tied to our knowledge of the 3D …

Monkeypox is a self-limiting zoonotic viral disease and causes smallpox-like symptoms. The
disease has a case fatality ratio of 3–6% and, recently, a multi-country outbreak of the …

Gastrointestinal diarrhea is majorly caused by the rotavirus (RV) in the children who
generally are under the age group of 5 years. WHO estimates that∼ 95% of the children …

The crown of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
constituted by its spike (S) glycoprotein. S protein mediates the SARS-CoV-2 entry into the …

In view of the increasing interest both in inhibitors of protein-protein interactions and in
protein drugs themselves, analysis of the three-dimensional structure of protein-protein …

Background Study of macromolecular assemblies is fundamental to understand functions in
cells. X-ray crystallography is the most common technique to solve their 3D structure at …

Background Protein–peptide and protein–protein interactions play an essential role in
different functional and structural cellular organizational aspects. While Cryo-EM and X-ray …

Herein, we present CONSRANK, a web tool for analyzing, comparing and ranking protein–
protein and protein–nucleic acid docking models, based on the conservation of inter-residue …

Herein, we present the results of a machine learning approach we developed to single out
correct 3D docking models of protein–protein complexes obtained by popular docking …

Abstract Background Molecular Dynamics (MD) simulations of protein complexes suffer from
the lack of specific tools in the analysis step. Analyses of MD trajectories of protein …