Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Microtubules are dynamic structures composed of α–β-tubulin heterodimers that are
essential in cell division and are important targets for cancer drugs. Mutations in β-tubulin …

G-CSF is a potent hematopoietic factor that enhances survival and drives differentiation of
myeloid lineage cells, resulting in the generation of neutrophilic granulocytes. Here, we …

The progression of neurogenesis relies on proneural basic helix–loop–helix (bHLH)
transcription factors. These factors operate in undifferentiated neural stem cells and induce …

The differential cellular expression of class III β‐tubulin isotype (βIII) is reviewed in the
context of human embryological development and neoplasia. As compared to somatic …

On the basis of preclinical studies that show overexpression of class III β-tubulin is
associated with resistance to tubulin-binding agents, several investigators have addressed …

The expression of the cytoskeletal protein class III β-tubulin isotype is reviewed in the
context of human central nervous system development and neoplasia. Compared to …

Microtubule proteins form a dynamic component of the cytoskeleton, and play key roles in
cellular processes, such as vesicular transport, cell motility and mitosis. Expression of …

The modern concept of neurogenesis in the adult brain is predicated on the premise that
multipotent glial cells give rise to new neurons throughout life. Although extensive evidence …

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS with both genetic and
environmental contributing factors. Clinical symptoms are broadly characterized by initial …