Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …

Medical digital twins are computational models of human biology relevant to a given medical
condition, which are tailored to an individual patient, thereby predicting the course of …

The COVID-19 pandemic has severely impacted health systems and economies worldwide.
Significant global efforts are therefore ongoing to improve vaccine efficacies, optimize …

Quantitative systems toxicology (QST) models are increasingly being applied for predicting
and understanding toxicity liabilities in pharmaceutical research and development. A …

Introduction Pharmacokinetic parameters assessment is a critical aspect of drug discovery
and development, yet challenges persist due to limited training data. Despite advancements …

Abstract Quantitative Systems Pharmacology (QSP) modeling is increasingly applied in the
pharmaceutical industry to influence decision making across a wide range of stages from …

Abstract 2023 marks the 10th anniversary of Natpara's submission to the US FDA, which led
to the first recorded regulatory interaction where a decision was supported by Quantitative …

Introduction While radiotherapy has long been recognized for its ability to directly ablate
cancer cells through necrosis or apoptosis, radiotherapy-induced abscopal effect suggests …

In recent years, computational cardiac electrophysiology simulations using mathematical
models have begun to be used in industrial and regulatory assessment of the proarrhythmic …

Computational, or in-silico, models are an effective, non-invasive tool for investigating
cardiovascular function. These models can be used in the analysis of experimental and …