Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …

Using data of the current prevalence of autism as 200: 10,000 and a 1: 2000 incidence of
definite mitochondrial (mt) disease, if there was no linkage of autism spectrum disorder …

Background Autism spectrum disorders (ASDs) are caused by both genetic and
environmental factors. Mitochondria act to connect genes and environment by regulating …

Autism spectrum disorders (ASDs) now affect 1–2% of the children born in the United States.
Hundreds of genetic, metabolic and environmental factors are known to increase the risk of …

Studies in human colonic cell lines and murine intestine suggest the presence of a Ca2+-
activated anion channel, presumably TMEM16a. Is there a potential for fluid secretion in …

Recent data suggest that defects in purinergic signalling are a common denominator of
autism spectrum disorders (ASDs), though nothing is known about whether the disorder …

Growing evidence implicates a key role for extracellular nucleotides in cellular regulation,
including of ion channels and renal function, but the mechanisms for such actions are …

Homeostatic control of plasma K+ is a necessary physiological function. The daily dietary K+
intake of~ 100 mmol is excreted predominantly by the distal tubules of the kidney. About …

Gut homeostasis results from complex neuro-immune interactions aimed at triggering
stereotypical and specific programs of coordinated mucosal secretion and powerful motor …

Are the symptoms of autism caused by a treatable metabolic syndrome that traces to the
abnormal persistence of a normal, alternative functional state of mitochondria? A small …