Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility

P Ssekamatte, OJ Sande, R Van Crevel… - Frontiers in …, 2023 - frontiersin.org
Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between
DM and major global diseases like tuberculosis (TB) is of great public health significance …

Neutrophil-Mediated Immunopathology and Matrix Metalloproteinases in Central Nervous System–Tuberculosis

XY Poh, FK Loh, JS Friedland, CWM Ong - Frontiers in Immunology, 2022 - frontiersin.org
Tuberculosis (TB) remains one of the leading infectious killers in the world, infecting
approximately a quarter of the world's population with the causative organism …

Identification of immune infiltration and cuproptosis-related molecular clusters in tuberculosis

S Li, Q Long, L Nong, Y Zheng, X Meng… - Frontiers in …, 2023 - frontiersin.org
Background Tuberculosis (TB) is an infectious disease caused by Mycobacterium
tuberculosis (Mtb) infection. Cuproptosis is a novel cell death mechanism correlated with …

Whole transcriptome sequencing reveals neutrophils' transcriptional landscape associated with active tuberculosis

X Geng, X Wu, Q Yang, H Xin, B Zhang… - Frontiers in …, 2022 - frontiersin.org
Neutrophils have been recognized to play an important role in the pathogenesis of
tuberculosis in recent years. Interferon-induced blood transcriptional signatures in ATB are …

[HTML][HTML] Major neutrophil-derived soluble mediators associate with baseline lung pathology and post-treatment recovery in tuberculosis patients

CN Muefong, O Owolabi, S Donkor… - Frontiers in …, 2021 - frontiersin.org
Background The inflammatory response to Mycobacterium tuberculosis results in variable
degrees of lung pathology during active TB (ATB) with central involvement of neutrophils …

Bioinformatics-led discovery of ferroptosis-associated diagnostic biomarkers and molecule subtypes for tuberculosis patients

D Wufuer, YY Li, H Aierken, JP Zheng - European journal of medical …, 2023 - Springer
Background Ferroptosis is closely associated with the pathophysiological processes of
many diseases, such as infection, and is characterized by the accumulation of excess lipid …

The levels of soluble CD137 are increased in tuberculosis patients and associated with disease severity and prognosis

L Yi, J Yan, P Wei, S Long, X Wang… - European Journal of …, 2024 - Wiley Online Library
Tuberculosis (TB) was the leading cause of death from a single infectious agent before the
coronavirus pandemic. Therefore, it is important to search for severity biomarkers and devise …

More severe lung lesions in smoker patients with active pulmonary tuberculosis were associated with peripheral NK cell subsets

Y Rao, W Cao, J Qu, X Zhang, J Wang, J Wang, G Li… - Tuberculosis, 2023 - Elsevier
Background Both pulmonary tuberculosis (PTB) and cigarette smoke (CS) exposure may
lead to lung damage. The potential impact of CS exposure on tuberculosis-associated lung …

Identifying the causal relationship between immune factors and osteonecrosis: a two-sample Mendelian randomization study

C Wang, Y Zhu, D Pan - Scientific Reports, 2024 - nature.com
A wealth of evidence intimates a profound connection between the immune system and
osteonecrosis, albeit the specific immune factors underlying this connection remain largely …

[HTML][HTML] Natural products in anti-tuberculosis host-directed therapy

X Huang, DB Lowrie, XY Fan, Z Hu - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Given that the disease progression of tuberculosis (TB) is primarily related to the host's
immune status, it has been gradually realized that chemotherapy that targets the bacteria …