Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments
The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …
related disorders remain unclear, but studies in depressed patients and rodent models are …
Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments
Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
[HTML][HTML] Cortical GABAergic dysfunction in stress and depression: new insights for therapeutic interventions
Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
Targeting glutamate signalling in depression: progress and prospects
Major depressive disorder (MDD) is severely disabling, and current treatments have limited
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …
Synaptic mechanisms regulating mood state transitions in depression
PK Parekh, SB Johnson, C Liston - Annual Review of …, 2022 - annualreviews.org
Depression is an episodic form of mental illness characterized by mood state transitions with
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …
Glutamate and gamma-aminobutyric acid systems in the pathophysiology of major depression and antidepressant response to ketamine
In patients with major depressive disorder or bipolar disorder, abnormalities in excitatory
and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional …
and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional …
Glutamate and GABA homeostasis and neurometabolism in major depressive disorder
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?
The discovery of the antidepressant effects of ketamine has opened a breakthrough
opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants …
opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants …
Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies
TH Pham, AM Gardier - Pharmacology & therapeutics, 2019 - Elsevier
Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor, displays
a fast antidepressant activity in treatment-resistant depression and in rodent models of …
a fast antidepressant activity in treatment-resistant depression and in rodent models of …
The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects
The ability of ketamine administration to activate prefrontal glutamate neurotransmission is
thought to be a key mechanism contributing to its transient psychotomimetic effects and its …
thought to be a key mechanism contributing to its transient psychotomimetic effects and its …