Voltage‐gated sodium channels initiate action potentials in nerve, muscle and other
excitable cells. The sodium current that initiates the nerve action potential was discovered by …

Voltage-gated sodium and calcium channels are evolutionarily related transmembrane
signaling proteins that initiate action potentials, neurotransmission, excitation-contraction …

Abstract Structure-based virtual screening is a key tool in early drug discovery, with growing
interest in the screening of multi-billion chemical compound libraries. However, the success …

The dorsal root ganglia–localized voltage-gated sodium (Nav) channel Nav1. 8 represents a
promising target for developing next-generation analgesics. A prominent characteristic of …

INTRODUCTION The nine subtypes of mammalian voltage-gated sodium (Nav) channels,
Nav1. 1 to Nav1. 9, are responsible for the initiation and propagation of action potentials in …

Brain voltage-gated sodium channel NaV1. 1 (SCN1A) loss-of-function variants cause the
severe epilepsy Dravet syndrome, as well as milder phenotypes associated with genetic …

INTRODUCTION Voltage-gated sodium (Nav) channels are responsible for the generation
and propagation of action potentials in excitable cells. They undergo voltage-dependent …

Voltage-gated sodium channel Na v 1.5 generates cardiac action potentials and initiates the
heartbeat. Here, we report structures of Na V 1.5 at 3.2–3.5 Å resolution. Na V 1.5 is …

Voltage-gated sodium (Nav) channels are targets of disease mutations, toxins, and
therapeutic drugs. Despite recent advances, the structural basis of voltage sensing …

INTRODUCTION Voltage-gated sodium (Nav) channels open and close ion-selective pores
in response to changes in membrane potential, and this gating underlies the generation of …