Background Multimorbidity is common, particularly among elderly people. Restructuring
health service systems to better manage this public health issue requires knowledge …

Frailty is a common geriatric syndrome characterized by increased vulnerability and is
associated with adverse clinical events such as falls, hospitalization, and death. Early …

Chronic inflammation is a well-established background process in many age-related
diseases. Many recent studies investigate the use of various inflammatory biomarkers such …

Background numerous studies point towards a critical role of Interleukin 6 (IL-6) pathway in
frailty pathogenesis yet the causal relationship between the two remains elusive. Methods …

Global concerted and sustained action is required under a rapid population ageing trend,
while global ageing varies across countries in space and time. To support global action on …

Frailty is a complex late life phenotype characterized by cumulative declines in multiple
physiological systems that increases the risk for disability and mortality. The biological …

Background: Posttraumatic stress disorder (PTSD) has been associated with increased
inflammation. C-reactive protein (CRP) is a marker of systemic inflammation, and recently …

Background The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on
mortality in individuals with colorectal cancer (CRC) remains unclear. Methods We …

C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation.
Many studies associated CRP level with diabetes and glucose levels, but the association of …

Background: Frailty is a common syndrome in elderly people, but has not been fully studied
in China. We aimed to investigate the epidemiological characteristics of frailty and analyze …