The standard model of adrenocortical zonation holds that the three main zones,
glomerulosa, fasciculata, and reticularis each have a distinct function, producing …

Stem cells are endowed with the potential for self-renewal and multipotency. Pluripotent
embryonic stem cells have an early role in the formation of the three germ layers (ectoderm …

Primary aldosteronism (PA) represents the most common cause of secondary hypertension,
but little is known regarding its adrenal cellular origins. Recently, aldosterone-producing cell …

Primary aldosteronism affects up to 10% of hypertensive patients and is responsible for
treatment resistance and increased cardiovascular risk. Here we perform a genome-wide …

Activating mutations in the canonical Wnt/β-catenin pathway are key drivers of hyperplasia,
the gateway for tumor development. In a wide range of tissues, this occurs primarily through …

Visualizing tissue distribution of steroid hormones is a promising application of MALDI mass
spectrometry imaging (MSI). On-tissue chemical derivatization using Girard's T reagent has …

The adult adrenal cortex is organized into concentric zones, each specialized to produce
distinct steroid hormones. Cellular composition of the cortex is highly dynamic and subject to …

Aldosterone and cortisol serve important roles in the pathogenesis of cardiovascular
diseases and metabolic disorders. Epigenetics is a mechanism to control enzyme …

Primary aldosteronism is a secondary hypertensive disease caused by autonomous
aldosterone production that often caused by an aldosterone-producing adenoma (APA) …

Resident progenitor and/or stem cell populations in the adult adrenal cortex enable cortical
cells to undergo homeostatic renewal and regeneration after injury. Renewal occurs …