To perceive their three-dimensional environment, cells and tissues must be able to sense
and interpret various physical forces like shear, tensile, and compression stress. These …

Collective cell motility is crucial to many biological processes including morphogenesis,
wound healing, and cancer invasion. Recently, the biology and biophysics communities …

The physical state of embryonic tissues emerges from non-equilibrium, collective
interactions among constituent cells. Cellular jamming, rigidity transitions and characteristics …

During embryogenesis tissue layers undergo morphogenetic flow rearranging and folding
into specific shapes. While developmental biology has identified key genes and local …

By definition of multicellularity, all animals need to keep their cells attached and intact,
despite internal and external forces. Cohesion between epithelial cells provides this key …

Single and collective cell migration are fundamental processes critical for physiological
phenomena ranging from embryonic development and immune response to wound healing …

Epithelial remodeling involves ratcheting behavior whereby periodic contractility produces
transient changes in cell-cell contact lengths, which stabilize to produce lasting …

During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by
mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal …

Mechanical stress can influence cell proliferation in vitro, but whether it makes a significant
contribution to growth control in vivo, and how it is modulated and experienced by cells …

INTRODUCTION How biological properties scale with organ or body size is a question
fundamental to development and physiology; however, at the cellular level, the scaling …