Progress and promise of alternative animal and non-animal methods in biomedical research

IA Freires, DFC Morelo, LFF Soares, IS Costa… - Archives of …, 2023 - Springer
Cell culture and invertebrate animal models reflect a significant evolution in scientific
research by providing reliable evidence on the physiopathology of diseases, screening for …

Alternatives of animal models for biomedical research: a comprehensive review of modern approaches

A Vashishat, P Patel, G Das Gupta… - Stem Cell Reviews and …, 2024 - Springer
Biomedical research has long relied on animal models to unravel the intricacies of human
physiology and pathology. However, concerns surrounding ethics, expenses, and inherent …

[HTML][HTML] Promising tools into oxidative stress: a review of non-rodent model organisms

Y Zhang, Y Li, T Ren, J Duan, P Xiao - Redox Biology, 2024 - Elsevier
Oxidative stress is a crucial concept in redox biology, and significant progress has been
made in recent years. Excessive levels of reactive oxygen species (ROS) can lead to …

Exploring the Anti-Osteoporotic Potential of Daucosterol: Impact on Osteoclast and Osteoblast Activities

S Lee, JH Kim, M Kim, S Hong, H Park, EJ Kim… - International Journal of …, 2023 - mdpi.com
Osteoporosis is a debilitating condition characterized by reduced bone mass and density,
leading to compromised structural integrity of the bones. While conventional treatments …

Mercuric sulfide nanoparticles suppress the neurobehavioral functions of Caenorhabditis elegans through a Skp1-dependent mechanism

L Li, Y Li, K Zeng, Q Wang - Food and Chemical Toxicology, 2024 - Elsevier
Cinnabar is the naturally occurring mercuric sulfide (HgS) and concerns about its safety
have been grown. However, the molecular mechanism of HgS-related neurotoxicity remains …

Microbial Transformation of Hesperidin and Biological Evaluation

D Kırcı, F Demirci, B Demirci - ACS omega, 2023 - ACS Publications
The main aim of the study was the biotransformation evaluation of hesperidin for
functionalization by 25 different nonhuman pathogenic microorganisms. As a result, four …

[HTML][HTML] Application of organoid technology in the human health risk assessment of microplastics: A review of progresses and challenges

J Cong, J Wu, Y Fang, J Wang, X Kong, L Wang… - Environment …, 2024 - Elsevier
Microplastic (MP) pollution has become a global environmental issue, and increasing
concern has been raised about its impact on human health. Current studies on the toxic …

Recent advances and perspectives on natural latex serum and its fractions for biomedical applications

RD Herculano, CU Mussagy, NB Guerra… - Biomaterials …, 2024 - Elsevier
Advances and the discovery of new biomaterials have opened new frontiers in regenerative
medicine. These biomaterials play a key role in current medicine by improving the life quality …

Reproductive toxicity by exposure to low concentrations of pesticides in Caenorhabditis elegans

A Moya, D Tejedor, M Manetti, A Clavijo, E Pagano… - Toxicology, 2022 - Elsevier
In view of the recurrent applications of pesticides in agricultural producing countries, the
increased presence of these substances in the environment raise a demand for the …

Biological Response Following the Systemic Injection of PEG–PAMAM–Rhodamine Conjugates in Zebrafish

B Custódio, P Carneiro, J Marques, V Leiro… - Pharmaceutics, 2024 - mdpi.com
Numerous therapeutic and diagnostic approaches used within a clinical setting depend on
the administration of compounds via systemic delivery. Biomaterials at the nanometer scale …