Pyrimidine nucleoside uridine plays a critical role in maintaining cellular function and energy
metabolism. In addition to its role in nucleoside synthesis, uridine and its derivatives …

Highlights•NAFLD is highly prevalent and affects at least one-third of the global
population.•Currently, there is no drug to cure NAFLD.•Fenofibrate is a PPARα agonist with …

Uridine (UR) is a pyrimidine nucleoside that plays an important role in regulating glucose
and lipid metabolism. The aim of this study was to investigate the effect of UR on obesity, fat …

Long-term hyperglycemia in diabetes mellitus is associated with complex damage to
cardiomyocytes and the development of mitochondrial dysfunction in the myocardium …

Nonalcoholic fatty liver disease (NAFLD) is initiated by excessive fat buildup in the liver,
affecting around 35% of the world population. Various circumstances contribute to the …

Uridine is a pyrimidine nucleoside that exerts restorative functions in tissues under stress.
Short-term co-administration of uridine with multiple unrelated drugs prevents drug-induced …

Background and Aims: Drug-induced steatosis is a major reason for drug failure in clinical
trials and post-marketing withdrawal; and therefore, predictive biomarkers are essential …

Carbohydrates have a protein sparing effect, but long-term feeding of a high-carbohydrate
diet (HCD) leads to metabolic disorders due to the limited utilization efficiency of …

Background Circulating levels of the pro-inflammatory cytokine interleukin-6 (IL-6) levels are
elevated in older adults, but mechanisms are unclear. In the current study, we used an …

To investigate the cumulative effects of maternal supplementation with nucleotides in the
form of uridine (UR) on fatty acid and amino acid constituents of neonatal piglets, fifty-two …