The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics
The complement system is one of the oldest known tightly regulated host defense systems
evolved for efficiently functioning cell-based immune systems and antibodies. Essentially …
evolved for efficiently functioning cell-based immune systems and antibodies. Essentially …
Healthy benefits and edible delivery systems of resveratrol: a review
Z Xie, X Chen - Food Reviews International, 2023 - Taylor & Francis
Resveratrol, as a promising bioactive, has received significant attention in the food industry
owing to its multiple health-benefits. The increasing studies on resveratrol encapsulation to …
owing to its multiple health-benefits. The increasing studies on resveratrol encapsulation to …
Rational design of antibody‐like peptides for targeting the human complement fragment protein C5a
Human complement fragment 5a (C5a) is one of the most potent glycoproteins generated
downstream of C3a and C4a during late‐stage activation of the complement signaling …
downstream of C3a and C4a during late‐stage activation of the complement signaling …
Structure of Designer Antibody-like Peptides Binding to the Human C5a with Potential to Modulate the C5a Receptor Signaling
C5a is an integral glycoprotein of the complement system that plays an important role in
inflammation and immunity. The physiological concentration of C5a is observed to be …
inflammation and immunity. The physiological concentration of C5a is observed to be …
Neutraligands of C5a can potentially occlude the interaction of C5a with the complement receptors C5aR1 and C5aR2
The complement system is central to the rapid immune response witnessed in vertebrates
and invertebrates, which plays a crucial role in physiology and pathophysiology …
and invertebrates, which plays a crucial role in physiology and pathophysiology …
Interaction of human C5a with the major peptide fragments of C5aR1: Direct evidence in support of “two-site” binding paradigm
The C5a receptor's (C5aR1) physiological function in various tissues depends on its high-
affinity binding to the cationic proinflammatory glycoprotein C5a, produced during the …
affinity binding to the cationic proinflammatory glycoprotein C5a, produced during the …
Ternary model structural complex of C5a, C5aR2, and β-arrestin1
Complement component fragment 5a (C5a) is one of the potent proinflammatory modulators
of the complement system. C5a recruits two genomically related G protein-coupled receptors …
of the complement system. C5a recruits two genomically related G protein-coupled receptors …
Conformational variants of the ternary complex of C5a, C5aR1, and G-protein
The complement component fragment 5a (C5a) binds and activates two complement
receptors like C5aR1 and C5aR2, which play a significant role in orchestrating the …
receptors like C5aR1 and C5aR2, which play a significant role in orchestrating the …
The role of human C5a as a non-genomic target in corticosteroid therapy for management of severe COVID19
Complement system plays a dual role; physiological as well as pathophysiological. While
physiological role protects the host, pathophysiological role can substantially harm the host …
physiological role protects the host, pathophysiological role can substantially harm the host …
Binding of raloxifene to human complement fragment 5a (hC5a): a perspective on cytokine storm and COVID19
R Mishra, LM Behera, S Rana - Journal of Biomolecular Structure …, 2022 - Taylor & Francis
Human C5a (hC5a), one of the pro-inflammatory glycoproteins of the complement system is
known to undergo production hyperdrive in response to stress and infection. hC5a has been …
known to undergo production hyperdrive in response to stress and infection. hC5a has been …