Role of epidermal growth factor receptor (EGFR) and its ligands in kidney inflammation and damage

S Rayego-Mateos, R Rodrigues-Diez… - Mediators of …, 2018 - Wiley Online Library
Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive
fibrosis, ultimately leading to end‐stage renal disease. Although many studies have …

Molecular pathways in peritoneal fibrosis

MS Balzer - Cellular signalling, 2020 - Elsevier
Peritoneal dialysis (PD) is a renal replacement therapy for patients with end-stage renal
disease that is equivalent to hemodialysis with respect to adequacy, mortality, and other …

CTGF in kidney fibrosis and glomerulonephritis

N Toda, M Mukoyama, M Yanagita, H Yokoi - Inflammation and …, 2018 - Springer
Background Glomerulonephritis, which causes inflammation in glomeruli, is a common
cause of end-stage renal failure. Severe and prolonged inflammation can damage glomeruli …

Fibrosis of peritoneal membrane as target of new therapies in peritoneal dialysis

V Masola, M Bonomini, S Borrelli, L Di Liberato… - International journal of …, 2022 - mdpi.com
Peritoneal dialysis (PD) is an efficient renal replacement therapy for patients with end-stage
renal disease. Even if it ensures an outcome equivalent to hemodialysis and a better quality …

Roles of the TGF-β–VEGF-C pathway in fibrosis-related lymphangiogenesis

H Kinashi, Y Ito, T Sun, T Katsuno, Y Takei - International journal of …, 2018 - mdpi.com
Lymphatic vessels drain excess tissue fluids to maintain the interstitial environment.
Lymphatic capillaries develop during the progression of tissue fibrosis in various clinical and …

The lymphatics in kidney health and disease

MD Donnan, Y Kenig-Kozlovsky… - Nature Reviews …, 2021 - nature.com
The mammalian vascular system consists of two networks: the blood vascular system and
the lymphatic vascular system. Throughout the body, the lymphatic system contributes to …

Tetramethylpyrazine ameliorates peritoneal angiogenesis by regulating VEGF/Hippo/YAP signaling

X Zhu, Y Shan, M Yu, J Shi, L Tang, H Cao… - Frontiers in …, 2021 - frontiersin.org
Angiogenesis of human peritoneal vascular endothelial cells (HPVECs), linked to vascular
endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR2) signaling, is a complication of …

HIF1A and VEGF regulate each other by competing endogenous RNA mechanism and involve in the pathogenesis of peritoneal fibrosis

J Li, SX Li, XH Gao, LF Zhao, J Du, TY Wang… - … -Research and Practice, 2019 - Elsevier
Background Peritoneal fibrosis is a major intractable complication of long-term peritoneal
dialysis, and would eventually lead to peritoneal ultrafiltration failure and the termination of …

CCN-based therapeutic peptides modify pancreatic ductal adenocarcinoma microenvironment and decrease tumor growth in combination with chemotherapy

A Resovi, P Borsotti, T Ceruti, A Passoni, M Zucchetti… - Cells, 2020 - mdpi.com
The prominent desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a
determinant factor in tumor progression and a major barrier to the access of chemotherapy …

Suppression of choroidal neovascularization and epithelial-mesenchymal transition in retinal pigmented epithelium by adeno-associated virus-mediated …

S Im, JW Han, EJ Park, JH Bang, HJ Shin, HS Chang… - Plos one, 2022 - journals.plos.org
Choroidal neovascularization (CNV) is a defining characteristic feature of neovascular age-
related macular degeneration (nAMD) that frequently results in irreversible vision loss. The …