Efficient entry into S phase of the cell cycle is necessary for embryonic development and
tissue homoeostasis. However, unscheduled S phase entry triggers DNA damage and …

Central nervous system tumors are a significant problem for modern medicine because of
their location. The explanation of the importance of microRNA (miRNA) in the development …

NUCKS1 (nuclear casein kinase and cyclin-dependent kinase substrate 1) is a 27 kD
chromosomal, vertebrate-specific protein, for which limited functional data exist. Here, we …

Chemotherapy resistance frequently drives tumour progression. However, the underlying
molecular mechanisms are poorly characterized. In this study, we explored miR-137's role in …

The effects of nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)
on tumor cells and the relevant mechanisms are less well defined. This study aimed to …

Nuclear, casein kinase and cyclin-dependent kinase substrate (NUCKS), a protein similar to
the HMG (high-mobility group) protein family, is one of the most modified proteins in the …

Background Non-small cell lung cancer (NSCLC) is a predominant type of lung cancer with
a high mortality rate. Objective The aim of this study is to investigate the roles of nuclear …

We identified a novel prognostic biomarker for the distant metastasis of colorectal cancer
(CRC) using comprehensive combined copy number and gene expression analyses …

In this work, we explored the intrinsic disorder status of the three members of the synuclein
family of proteins—α-, β-, and γ-synucleins—and showed that although all three human …

Although much is known about the molecular players in insulin signaling, there is scant
information about transcriptional regulation of its key components. We now find that NUCKS …