Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

The biocatalytic activity of transglutaminases (TGs) leads to the synthesis of new covalent
isopeptide bonds (crosslinks) between peptide-bound glutamine and lysine residues, but …

Cancers harbor significant genetic heterogeneity and patterns of relapse following many
therapies are due to evolved resistance to treatment. While efforts have been made to …

Malignant tumors remain one of the main sources of morbidity and mortality around the
world. A chemotherapeutic approach to cancer treatment poses a multitude of challenges …

Abstract Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that
catalyzes Ca (2+)-dependent protein modifications. In addition to being an enzyme, TG2 …

TGM2 is a stress-responsive gene that encodes a multifunctional and structurally complex
protein called tissue transglutaminase (abbreviated as TG2 or tTG). TGM2 expression is …

Transglutaminase 2 (TG2) has emerged as a key cancer cell survival factor that drives
epithelial to mesenchymal transition, angiogenesis, metastasis, inflammation, drug …

Lung-resident neutrophils need to be tightly regulated to avoid degranulation-and cytokine-
associated damage to fragile alveolar structures that can lead to fatal outcomes. Here we …

Tissue transglutaminase (TG2) is a member of the transglutaminase family that catalyzes
Ca2+-dependent protein crosslinks and hydrolyzes guanosine 5′-triphosphate (GTP). The …