Genome-wide association (GWA) studies are an effective approach for identifying genetic
variants associated with disease risk. GWA studies can be confounded by population …

Background Restless legs syndrome is a prevalent chronic neurological disorder with
potentially severe mental and physical health consequences. Clearer understanding of the …

We show that epigenome-and transcriptome-wide association studies (EWAS and TWAS)
are prone to significant inflation and bias of test statistics, an unrecognized phenomenon …

Population stratification—allele frequency differences between cases and controls due to
systematic ancestry differences—can cause spurious associations in disease studies. We …

Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We
report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated …

Obesity results from the interaction of genetic and environmental factors. To search for
sequence variants that affect variation in two common measures of obesity, weight and body …

Smoking is a leading cause of preventable death, causing about 5 million premature deaths
worldwide each year,. Evidence for genetic influence on smoking behaviour and nicotine …

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of inflammatory responses and thus have important roles in the pathogenesis of …

Genome‐wide association studies (GWAS) are being conducted at an unprecedented rate
in population‐based cohorts and have increased our understanding of the pathophysiology …

Hair, skin and eye colors are highly heritable and visible traits in humans. We carried out a
genome-wide association scan for variants associated with hair and eye pigmentation, skin …