Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

Sprouting angiogenesis is a dynamic process in which endothelial cells collectively migrate,
shape new lumenized tubes, make new connections, and remodel the nascent network into …

Endothelial cells (ECs) provide angiocrine factors orchestrating tumor progression. Here, we
show that activated Notch1 receptors (N1ICD) are frequently observed in ECs of human …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it is
unknown if it acts solely by inhibiting cancer cell autophagy. We report that CQ reduced …

Several vascular endothelial growth factor (VEGF)-targeted agents, administered either as
single agents or in combination with chemotherapy, have been shown to benefit patients …

Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is
common in many types of cancer, and generally confers a poor prognosis. Known to induce …

The Notch pathway is a highly conserved signaling system that controls a diversity of growth,
differentiation, and patterning processes. In growing blood vessels, sprouting of endothelial …

The past two decades of angiogenesis research have identified a wealth of pro-and
antiangiogenic signals originating from the tissue environment, which control blood vessel …

The endothelial barrier strictly maintains vascular and tissue homeostasis, and therefore
modulates many physiological processes such as angiogenesis, immune responses, and …