The biogenic amine, histamine, has been shown to critically modulate inflammatory
processes as well as the properties of neurons and synapses in the brain, and is also …

Alzheimer's disease is a neurodegenerative disorder characterized by extracellular amyloid
plaque deposits, mainly composed of amyloid-beta peptide and intracellular neurofibrillary …

The cerebellum plays a critical role in all vertebrates, and many neurological disorders are
associated with cerebellum dysfunction. A major limitation in cerebellar research has been …

Histamine appears early during brain development, has been shown to regulate fetal and
adult brain-derived stem cells in a receptor type-dependent manner, and has widespread …

Multi-target-directed ligands seem to be an interesting approach to the treatment of complex
disorders such as Alzheimer's disease. The aim of the present study was to find novel …

Evidence points to a dual role of histamine in microglia-mediated neuroinflammation, a key
pathological feature of several neurodegenerative pathologies. Moreover, histamine has …

The purpose of this review was to search for experimental or clinical evidence on the effect
of hyperglycemia in fetal programming to neurological diseases, excluding evident neural …

The neurological recovery following traumatic brain injury (TBI) is limited, largely due to a
deficiency in neurogenesis. The present study explores the effects of histamine H3 receptor …

Alzheimer's disease (AD) represents the principal cause of dementia among the elderly.
Great efforts have been established to understand the physiopathology of AD. Changes in …

Background H1 antihistamines (AHs), categorized as first-generation antihistamines (FGAs)
or second-generation antihistamines (SGAs), possess anticholinergic properties linked to …