Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

CL Kuo, A Ponneri Babuharisankar, YC Lin… - Journal of biomedical …, 2022 - Springer
The major concept of" oxidative stress" is an excess elevated level of reactive oxygen
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …

Reactive oxygen species (ROS) in macrophage activation and function in diabetes

E Rendra, V Riabov, DM Mossel, T Sevastyanova… - Immunobiology, 2019 - Elsevier
In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This
contributes to the vascular complications of diabetes. Recent studies have shown that ROS …

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

M Genin, F Clement, A Fattaccioli, M Raes, C Michiels - BMC cancer, 2015 - Springer
Abstract Background Tumor associated macrophages (TAMs) are present in high density in
solid tumors. TAMs share many characteristics with alternatively activated macrophages …

Tumor-associated macrophages as major players in the tumor microenvironment

T Chanmee, P Ontong, K Konno, N Itano - Cancers, 2014 - mdpi.com
During tumor progression, circulating monocytes and macrophages are actively recruited
into tumors where they alter the tumor microenvironment to accelerate tumor progression …

Roles of microglia in brain development, tissue maintenance and repair

MA Michell-Robinson, H Touil, LM Healy, DR Owen… - Brain, 2015 - academic.oup.com
The emerging roles of microglia are currently being investigated in the healthy and diseased
brain with a growing interest in their diverse functions. In recent years, it has been …

Anti‐inflammatory Effects of Empagliflozin and Gemigliptin on LPS‐Stimulated Macrophage via the IKK/NF‐κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways

N Lee, YJ Heo, SE Choi, JY Jeon… - Journal of …, 2021 - Wiley Online Library
Background. Sodium‐glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase‐4 (DPP‐4)
inhibitors are glucose‐lowering drugs whose anti‐inflammatory properties have recently …

[HTML][HTML] Regulation of innate immunity by Nrf2

D van der Horst, ME Carter-Timofte… - Current Opinion in …, 2022 - Elsevier
The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly
investigated as a regulator of redox homeostasis. However, research over the past years …

Distinct macrophage phenotypes contribute to kidney injury and repair

S Lee, S Huen, H Nishio, S Nishio, HK Lee… - Journal of the …, 2011 - journals.lww.com
The ischemically injured kidney undergoes tubular cell necrosis and apoptosis,
accompanied by an interstitial inflammatory cell infiltrate. In this study, we show that iNos …

PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties

MA Bouhlel, B Derudas, E Rigamonti, R Dièvart… - Cell metabolism, 2007 - cell.com
Th1 cytokines promote monocyte differentiation into proatherogenic M1 macrophages, while
Th2 cytokines lead to an" alternative" anti-inflammatory M2 macrophage phenotype. Here …

Comparison of polarization properties of human adult microglia and blood‐derived macrophages

BA Durafourt, CS Moore, DA Zammit, TA Johnson… - Glia, 2012 - Wiley Online Library
Both microglia, the resident myeloid cells of the CNS parenchyma, and infiltrating blood‐
derived macrophages participate in inflammatory responses in the CNS. Macrophages can …