Mass spectrometry imaging (MSI) is a powerful tool that enables untargeted investigations
into the spatial distribution of molecular species in a variety of samples. It has the capability …

High parameter imaging is an important tool in the life sciences for both discovery and
healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging …

The systematic study of the temperature and pressure dependence of matrix-assisted
ionization (MAI) led us to the discovery of the seemingly impossible, initially explained by …

Due to their involvement in numerous biochemical pathways, neuropeptides have been the
focus of many recent research studies. Unfortunately, classic analytical methods, such as …

This Tutorial is to provide a summary of parameters useful for successful outcomes of
laserspray ionization (LSI) and related methods that employ a laser to ablate a matrix …

In this work, we demonstrate rapid, high spatial, and high spectral resolution imaging of
intact proteins by matrix-assisted laser desorption/ionization (MALDI) imaging mass …

The structural information and spatial distribution of molecules in biological tissues are
closely related to the potential molecular mechanisms of disease origin, transfer, and …

Together with my group and collaborators, I have been fortunate to have had a key role in
the discovery of new ionization processes that we developed into new flexible, sensitive …

Introduced in 2000, atmospheric pressure (AP)/matrix-assisted laser desorption/ionization
(MALDI) has attracted substantial attention in the mass spectrometry community due to its …

Vacuum matrix-assisted ionization (vMAI) uses select matrix compounds which when
exposed to the vacuum of a mass spectrometer produce gas-phase ions from associated …