The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Wireless on-demand drug delivery systems exploit exogenous stimuli—acoustic waves,
electric fields, magnetic fields and electromagnetic radiation—to trigger drug carriers. The …

Ultrasmall gold nanoclusters (AuNCs) have emerged as agile probes for in vivo imaging, as
they exhibit exceptional tumour accumulation and efficient renal clearance properties …

In vivo biosensors are emerging as powerful tools in biomedical research and diagnostic
medicine. Distinct from “labels” or “imaging”, in vivo biosensors are designed for continuous …

We are in the midst of a technological revolution that is providing new insights into human
biology and cancer. In this era of big data, we are amassing large amounts of information …

Tumor cells are hypothesized to use proteolytic enzymes to facilitate invasion. Whether
circulating tumor cells (CTCs) secrete these enzymes to aid metastasis is unknown. A …

Connecting neural circuit output to behaviour can be facilitated by the precise chemical
manipulation of specific cell populations,. Engineered receptors exclusively activated by …

Human breath contains many volatile metabolites. However, few breath tests are currently
used in the clinic to monitor disease due to bottlenecks in biomarker identification. Here we …

Cancer biomarkers with high selectivity, specificity and reproducibility play essential role in
diagnosis, prognosis and prediction of treatment efficacy in cancer patients. However, the …

Progress in nanotechnology has enabled us to open many new fronts in biomedical
research by exploiting the peculiar properties of materials at the nanoscale. The thermal …