SUMOtherapeutics for ischemic stroke
The small, ubiquitin-like modifier (SUMO) is a post-translational modifier with a profound
influence on several key biological processes, including the mammalian stress response. Of …
influence on several key biological processes, including the mammalian stress response. Of …
The Role of Histone Deacetylases in Epilepsy: From lactate metabolism to protein lactylation
X Kuang, S Chen, Q Ye - Frontiers in Cellular Neuroscience, 2025 - frontiersin.org
Protein lactylation is a new form of protein post-translational modification that has been
proposed recently. Lactoyl groups are mainly converted from the glycolytic product lactate …
proposed recently. Lactoyl groups are mainly converted from the glycolytic product lactate …
Verapamil inhibits TXNIP-NLRP3 inflammasome activation and preserves functional recovery after intracerebral hemorrhage in mice
Intracerebral hemorrhage (ICH) is the second most common type of stroke with no
satisfactory treatment. Recent studies from our group and others indicated a potential …
satisfactory treatment. Recent studies from our group and others indicated a potential …
Selective HDAC6 inhibition protects against blood–brain barrier dysfunction after intracerebral hemorrhage
C Peng, Y Wang, Z Hu, C Chen - CNS Neuroscience & …, 2024 - Wiley Online Library
Backgrounds Blood–brain barrier (BBB) disruption after intracerebral hemorrhage (ICH)
significantly induces neurological impairment. Previous studies showed that HDAC6 …
significantly induces neurological impairment. Previous studies showed that HDAC6 …
Restoration of HDAC1 enzymatic activity after stroke protects neurons from ischemia/reperfusion damage and attenuates behavioral deficits in rats
JS Chen, HK Wang, YT Su, CY Hsu, JS Chen… - International Journal of …, 2021 - mdpi.com
A therapeutic approach for promoting neuroprotection and brain functional regeneration
after strokes is still lacking. Histone deacetylase 1 (HDAC1), which belongs to the histone …
after strokes is still lacking. Histone deacetylase 1 (HDAC1), which belongs to the histone …
The use of nanocarriers to enhance the anti-neuroinflammatory potential of dietary flavonoids in animal models of neurodegenerative diseases: A systematic review
Background: Neurodegenerative diseases (NDs) have become a common and growing
cause of mortality and morbidity worldwide, especially in older adults. The natural flavonoids …
cause of mortality and morbidity worldwide, especially in older adults. The natural flavonoids …
Entinostat Improves Motor Function and Neuronal Damage Via Downregulating NLRP3 Inflammasome Activation After Spinal Cord Injury
C Dai, B Liu, B Peng, B Qu, J Lin, B Peng… - Frontiers in …, 2021 - frontiersin.org
Background: Spinal cord injury (SCI), a major public health problem, has no effective
treatment. A large number of studies have confirmed that histone deacetylases (HDACs) are …
treatment. A large number of studies have confirmed that histone deacetylases (HDACs) are …