Kidney failure is associated with high morbidity and mortality. Hemodialysis, the most
prevalent modality of renal replacement therapy, uses the principle of semipermeable …

A hallmark of chronic kidney disease is the retention of solutes that normally are eliminated
by the kidneys. The current classification defines uremic toxins based on molecular weight …

During the last decades, various strategies have been optimized to enhance clearance of a
variable spectrum of retained molecules to ensure hemodynamic tolerance to fluid removal …

Background: Medium cut-off (MCO) membranes enhance large middle-molecule clearance
while selectively retaining molecules> 45 000 Da. Objectives: We undertook a systematic …

Chronic kidney disease (CKD) is characterized by the retention of solutes named uremic
toxins, which strongly associate with high morbidity and mortality. Mounting evidence …

Background: A novel medium cut-off (MCO) dialyzer (Theranova, Baxter Healthcare,
Deerfield, IL, USA) enhances large middle molecule clearance while retaining selectivity for …

Background: To observe the efficacy and safety of roxadustat, an inhibitor of proline
hydroxylase, in renal allograft anemia patients. Methods: This prospective study collected …

Background Resistance to erythropoiesis-stimulating agents (ESA) is associated with
adverse outcomes in patients undergoing chronic hemodialysis. However, the impact of …

Expanded hemodialysis (HDx), using medium cut‐off membrane, is a novel therapy that
effectively clears middle molecules (MMs). We aimed to compare HDx to hemodiafiltration …

Medium cut‐off (MCO) dialyzers were designed to provide better clearance of uremic toxins.
We conducted a meta‐analysis comparing MCO with high‐flux (HF) dialyzers for the effect …