Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …

The prevalence of obesity in adults and children is rapidly increasing across the world.
Several general (patho) physiological alterations associated with obesity have been …

Tacrolimus (Tac) is widely used for the prevention of rejection after solid organ
transplantation. Finding the optimal balance between effective Tac concentrations and …

Abstract Background Growth faltering in West African children has previously been
associated with dietary exposure to aflatoxins, particularly upon weaning. However, in …

Objective Although the human small intestine serves primarily as an absorptive organ for
nutrients and water, it also has the ability to metabolise drugs. Interest in the small intestine …

Gut microbiota in interaction with intestinal host tissues influences many brain functions and
microbial dysbiosis has been linked with brain disorders, such as neuropsychiatric …

Clinical studies comparing the response and side effects of various opioids have not been
able to show robust differences between drugs. Hence, recommendations of the regulatory …

Alkylating agents are genotoxic chemicals that can induce and treat various types of cancer.
This occurs through covalent bonding with cellular macromolecules, in particular DNA …

Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure
to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights …

Despite a lower content of many drug metabolising enzymes in the intestinal epithelium
compared to the liver (eg intestinal CYP3A abundance in the intestine is 1% that of the liver) …