Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Introduction: Sleep disorders, especially insomnia, are very common in different kinds of
cancers, but their prevalence and incidence are not well-known. Disturbed sleep in cancer is …

1.0 BACKGROUND ACTIGRAPHY HAS BEEN USED TO STUDY SLEEP/WAKE PATTERNS
FOR OVER 20 YEARS. The advantage of actigraphy over traditional polysomnography …

What is the little button for? This button is pushed at bedtime and awake time to let the
research know what time you went to bed and got up. This button can also be used with the …

Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …

Fatigue is one of the most common and debilitating symptoms experienced by patients with
cancer. Cancer-related fatigue (CRF) is characterized by feelings of tiredness, weakness …

Epidemiological studies indicate that stress, chronic depression and lack of social support
might serve as risk factors for cancer development and progression. Recent cellular and …

This article reviews various procedures used in the analysis of circadian rhythms at the
populational, organismal, cellular and molecular levels. The procedures range from visual …