Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies
Three decades of p53 research have led to many advances in understanding the basic
biology of normal and cancer cells. Nonetheless, the detailed functions of p53 in normal …
biology of normal and cancer cells. Nonetheless, the detailed functions of p53 in normal …
p53's extended reach: The mutant p53 secretome
E Pavlakis, T Stiewe - Biomolecules, 2020 - mdpi.com
p53 suppresses tumorigenesis by activating a plethora of effector pathways. While most of
these operate primarily inside of cells to limit proliferation and survival of incipient cancer …
these operate primarily inside of cells to limit proliferation and survival of incipient cancer …
Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis
Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases,
the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is …
the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is …
Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells
RNA-based regulation and CRISPR/Cas transcription factors (CRISPR-TFs) have the
potential to be integrated for the tunable modulation of gene networks. A major limitation of …
potential to be integrated for the tunable modulation of gene networks. A major limitation of …
p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner
A Molchadsky, I Shats, N Goldfinger… - PloS one, 2008 - journals.plos.org
Background The tumor suppressor p53 is an important regulator that controls various
cellular networks, including cell differentiation. Interestingly, some studies suggest that p53 …
cellular networks, including cell differentiation. Interestingly, some studies suggest that p53 …
A tunable dual‐promoter integrator for targeting of cancer cells
L Nissim, RH Bar‐Ziv - Molecular systems biology, 2010 - embopress.org
Precise discrimination between similar cellular states is essential for autonomous decision‐
making scenarios, such as in vivo targeting of diseased cells. Discrimination could be …
making scenarios, such as in vivo targeting of diseased cells. Discrimination could be …
p53‐repressed miRNAs are involved with E2F in a feed‐forward loop promoting proliferation
Normal cell growth is governed by a complicated biological system, featuring multiple levels
of control, often deregulated in cancers. The role of microRNAs (miRNAs) in the control of …
of control, often deregulated in cancers. The role of microRNAs (miRNAs) in the control of …
Genome‐wide transcriptome analyses reveal p53 inactivation mediated loss of miR‐34a expression in malignant peripheral nerve sheath tumours
S Subramanian, V Thayanithy, RB West… - The Journal of …, 2010 - Wiley Online Library
Malignant peripheral nerve sheath tumours (MPNSTs) are aggressive soft tissue tumours
that occur either sporadically or in patients with neurofibromatosis type 1. The malignant …
that occur either sporadically or in patients with neurofibromatosis type 1. The malignant …
Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival
The microRNA miR-504 targets TP53 mRNA encoding the p53 tumor suppressor. miR-504
resides within the fibroblast growth factor 13 (FGF13) gene, which is overexpressed in …
resides within the fibroblast growth factor 13 (FGF13) gene, which is overexpressed in …
Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature
H Solomon, Y Buganim, I Kogan-Sakin… - Journal of cell …, 2012 - journals.biologists.com
Concomitant expression of mutant p53 and oncogenic Ras, leading to cellular
transformation, is well documented. However, the mechanisms by which the various mutant …
transformation, is well documented. However, the mechanisms by which the various mutant …