Simple Summary Selective killing of cancer cells is privileged mainstream in cancer
treatment and targeted therapy represents the new tool with a potential to pursue this aim. It …

Disruption of cell cycle checkpoints has been well established as a hallmark of cancer. In
particular, the G1-S transition mediated by the cyclin D-cyclin-dependent kinase 4/6 …

Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

The DNA damage response (DDR) is an elegant system, coordinating DNA repair with cell
cycle checkpoints, that evolved to protect living organisms from the otherwise fatal levels of …

Proliferating cells regularly experience replication stress caused by spontaneous DNA
damage that results from endogenous reactive oxygen species (ROS), DNA sequences that …

Acute myeloid leukemia (AML) comprises a multifarious and heterogeneous array of
illnesses characterized by the anomalous proliferation of myeloid cells in the bone marrow …

Acute myeloid leukemia (AML) is the most common adult acute leukemia. Survival remains
poor, despite decades of scientific advances. Cytotoxic induction chemotherapy regimens …

High-mobility group AT-hook 2 (HMGA2) is a nonhistone chromatin-binding protein that is
normally expressed in stem cells of various tissues and aberrantly detected in several tumor …

Objective: Pulmonary arterial hypertension (PAH) is a debilitating disease associated with
progressive vascular remodeling of distal pulmonary arteries leading to elevation of …

Cell cycle checkpoint activation promotes DNA damage repair, which is highly associated
with the chemoresistance of various cancers including acute myeloid leukemia (AML) …