The brain is a vital organ, susceptible to alterations under genetic influences and
environmental experiences. Social isolation (SI) acts as a stressor which results in …

Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

Where and how does the brain code reward during social behavior? Almost all elements of
the brain's reward circuit are modulated during social behavior. The striatum in particular is …

Exposing mammals to early-life adverse events, including maternal separation or social
isolation, profoundly affects brain development and adult behaviour and may contribute to …

Adolescence is a developmental period associated with vast neural and behavioral changes
which are accompanied by altered sensitivity to stimuli, both stressful and rewarding …

Severe deprivation in the first few years of life is associated with multiple difficulties in
cognition and behavior. However, the brain basis for these difficulties is poorly understood …

Exposure to adverse experiences in early-life is implicated in the later vulnerability to
development of psychiatric disorders, including anxiety and affective disorders in humans …

The prefrontal cortex (PFC) efferent projections to limbic areas facilitate a top-down control
on the execution of goal-directed behaviours. The PFC sends glutamatergic outputs to limbic …

Environmental enrichment during development produces a host of neurobehavioral effects
in preclinical models. Early work demonstrated that enrichment enhances learning of a …

Social isolation (SI) rearing, a model of early life stress, results in profound behavioral
alterations, including increased anxiety‐like behavior, impaired sensorimotor gating and …