Recent advances in the development of in situ gelling drug delivery systems for non-parenteral administration routes

B Vigani, S Rossi, G Sandri, MC Bonferoni… - Pharmaceutics, 2020 - mdpi.com
In situ gelling drug delivery systems have gained enormous attention over the last decade.
They are in a sol-state before administration, and they are capable of forming gels in …

Transfersomes: a revolutionary nanosystem for efficient transdermal drug delivery

MW Akram, H Jamshaid, FU Rehman, M Zaeem… - AAPS …, 2022 - Springer
Transdermal delivery system has gained significance in drug delivery owing to its
advantages over the conventional delivery systems. However, the barriers of stratum …

Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

DD Nguyen, JY Lai - Polymer Chemistry, 2020 - pubs.rsc.org
The development of efficient therapies for ocular diseases remains a significant challenge
because of the static and dynamic barriers in the eye. A variety of pharmaceutical strategies …

[HTML][HTML] Ciprofloxacin loaded nanostructured lipid carriers incorporated into in-situ gels to improve management of bacterial endophthalmitis

A Youssef, N Dudhipala, S Majumdar - Pharmaceutics, 2020 - mdpi.com
Bacterial endophthalmitis (BE) is a potentially sight-threatening inflammatory reaction of the
intraocular fluids or tissues caused by bacteria. Ciprofloxacin (CIP) eye drops are prescribed …

Effect of lipid and edge activator concentration on development of aceclofenac-loaded transfersomes gel for transdermal application: in vitro and ex vivo skin …

N Dudhipala, R Phasha Mohammed… - Drug development …, 2020 - Taylor & Francis
The present investigation focused mainly on the development of aceclofenac (AF) loaded
transfersomal gel (AF-TG) to minimize the frequency of oral dosing during the treatment of …

[HTML][HTML] Neuroprotective effect of ropinirole lipid nanoparticles enriched hydrogel for parkinson's disease: In vitro, ex vivo, pharmacokinetic and pharmacodynamic …

N Dudhipala, T Gorre - Pharmaceutics, 2020 - mdpi.com
Parkinson's disease (rp) is a progressive neurodegenerative disorder. Ropinirole (RP) is a
newer generation dopamine agonist used for the treatment of PD. It is prescribed as oral …

Lipid-based nanovesicular drug delivery systems

T Limongi, F Susa, M Marini, M Allione, B Torre… - Nanomaterials, 2021 - mdpi.com
In designing a new drug, considering the preferred route of administration, various
requirements must be fulfilled. Active molecules pharmacokinetics should be reliable with a …

Dual drug loaded lipid nanocarrier formulations for topical ocular applications

AAA Youssef, N Dudhipala… - International journal of …, 2022 - Taylor & Francis
Introduction Untreated ocular infections can damage the unique fine structures of the eye
with possible visual impairments and blindness. Ciprofloxacin (CIP) ophthalmic solution is …

Study the antifungal and ocular permeation of ketoconazole from ophthalmic formulations containing trans-ethosomes nanoparticles

TA Ahmed, MM Alzahrani, A Sirwi, NA Alhakamy - Pharmaceutics, 2021 - mdpi.com
Ketoconazole (KET), a synthetic imidazole broad-spectrum antifungal agent, is
characterized by its poor aqueous solubility and high molecular weight, which might hamper …

Effects of nanoparticle deformability on multiscale biotransport

HH Gadalla, Z Yuan, Z Chen, F Alsuwayyid… - Advanced Drug Delivery …, 2024 - Elsevier
Deformability is one of the critical attributes of nanoparticle (NP) drug carriers, along with
size, shape, and surface properties. It affects various aspects of NP biotransport, ranging …