Airflow and particle transport in the human respiratory system

C Kleinstreuer, Z Zhang - Annual review of fluid mechanics, 2010 - annualreviews.org
Airflows in the nasal cavities and oral airways are rather complex, possibly featuring a
transition to turbulent jet-like flow, recirculating flow, Dean's flow, vortical flows, large …

A review of respiratory anatomical development, air flow characterization and particle deposition

MS Islam, G Paul, HX Ong, PM Young, YT Gu… - International journal of …, 2020 - mdpi.com
The understanding of complex inhalation and transport processes of pollutant particles
through the human respiratory system is important for investigations into dosimetry and …

[HTML][HTML] Particle deposition in a realistic geometry of the human conducting airways: Effects of inlet velocity profile, inhalation flowrate and electrostatic charge

PG Koullapis, SC Kassinos, MP Bivolarova… - Journal of …, 2016 - Elsevier
Understanding the multitude of factors that control pulmonary deposition is important in
assessing the therapeutic or toxic effects of inhaled particles. The use of increasingly …

Regional aerosol deposition in the human airways: The SimInhale benchmark case and a critical assessment of in silico methods

P Koullapis, SC Kassinos, J Muela… - European Journal of …, 2018 - Elsevier
Regional deposition effects are important in the pulmonary delivery of drugs intended for the
topical treatment of respiratory ailments. They also play a critical role in the systemic delivery …

Modeling airflow and particle transport/deposition in pulmonary airways

C Kleinstreuer, Z Zhang, Z Li - Respiratory physiology & neurobiology, 2008 - Elsevier
A review of research papers is presented, pertinent to computer modeling of airflow as well
as nano-and micron-size particle deposition in pulmonary airway replicas. The key modeling …

On intra-and intersubject variabilities of airflow in the human lungs

J Choi, MH Tawhai, EA Hoffman, CL Lin - Physics of Fluids, 2009 - pubs.aip.org
The effects of intra-and intersubject variabilities in airway geometry on airflow in the human
lungs are investigated by large eddy simulation. The airway models of two human subjects …

In vitro dose comparison of Respimat® inhaler with dry powder inhalers for COPD maintenance therapy

AM Ciciliani, P Langguth, H Wachtel - International journal of …, 2017 - Taylor & Francis
Background Combining in vitro mouth–throat deposition measurements, cascade impactor
data and computational fluid dynamics (CFD) simulations, four different inhalers were …

Large eddy and detached eddy simulations of fluid flow and particle deposition in a human mouth–throat

ST Jayaraju, M Brouns, C Lacor, B Belkassem… - Journal of Aerosol …, 2008 - Elsevier
Fluid flow was simulated in a human mouth–throat model under normal breathing conditions
(30l/min) alternatively employing RANS k–ω (without near-wall corrections), DES and LES …

Laminar‐to‐turbulent fluid–nanoparticle dynamics simulations: Model comparisons and nanoparticle‐deposition applications

Z Zhang, C Kleinstreuer - International Journal for Numerical …, 2011 - Wiley Online Library
Relying on benchmark experimental data sets for flow in conduits with local constrictions,
LES and three widely used RANS turbulence models, ie the low Reynolds number (LRN) k …

Three-dimensional inspiratory flow in the upper and central human airways

AJ Banko, F Coletti, D Schiavazzi, CJ Elkins… - Experiments in …, 2015 - Springer
The steady inspiratory flow through an anatomically accurate model of the human airways
was studied experimentally at a regime relevant to deep inspiration for aerosol drug …