Although several randomized controlled trials (RCTs) have shown the efficacy of
antifibrinolytic drugs in liver transplantation, their use remains debated due to concern for …

Background Excessive blood loss and increased blood transfusion requirements may have
significant impact on the short‐term and long‐term outcomes after liver transplantation …

Abstract Large doses of aprotinin (1,000,000-2,000,000 kallikrein inhibitor units [KIU] initial
dose and a 500,000 KIU/h infusion) have been used during orthotopic liver transplantation …

Fibrinolysis has been recognized as an important cause of intraoperative bleeding during
orthotopic liver transplantation (OLT). Several investigators have used prophylactic …

Liver transplantation is frequently complicated by hemostatic defects associated with end-
stage liver disease, surgical bleeding, and the grafted organ recovering from ischemia and …

Blood transfusion can adversely affect patient outcome and graft survival in orthotopic liver
transplantation (OLT). With this respect, prophylactic aprotinin administration decreases …

OBJECTIVE: To review the clinical pharmacology of aprotinin in patients undergoing
surgical procedures involving major blood loss, namely, coronary artery bypass graft …

Las principales alternativas farmacológicas a la transfusión sanguínea son los inhibidores
de las serinproteasas (aprotinina), los antifibrinolíticos (ácido ɛ-aminocaproico y ácido …

Numerous transfusion issues arise in the support of solid organ transplantation. ABO and
HLA can cause graft rejection immunity or problems in transfusion support. Blood usage has …

The origin of blood loss during liver surgery is multifactorial. Surgical skill, technique,
anesthesiological care, but also hyperfibrinolysis have been shown to play a role in the …