Cognitive processes, particularly learning and memory, are crucial brain mechanisms
mediating the successful adaptation of individuals to constantly changing environmental …

G protein‐coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across cell membranes and represent major targets in the development of …

G-protein coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across membranes, and represent major targets in the development of novel …

Sphingolipids are essential constituents of the plasma membrane (PM) and play an
important role in signal transduction by modulating clustering and dynamics of membrane …

Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most
behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental …

Alcohol use disorder and depression show a high comorbidity at clinical level with no
treatment available selectively for this condition. A hyperfunction of acid sphingomyelinase …

Receptors on cell membrane bind to their respective ligands and transduce intracellular
signals resulting in variety of effector functions. Membrane lipid composition determines the …

Alcohol exposure alters the signaling of the serotoninergic system, which is involved in
alcohol consumption, reward, and dependence. In particular, dysregulation of serotonin …

Sphingolipids are essential components of eukaryotic cell membranes and are thought to be
involved in a variety of cellular functions. Sphingomyelin is the most abundant sphingolipid …

G protein‐coupled receptors (GPCRs) are vital cellular signaling machinery and currently
represent~ 40% drug targets. Endocytosis of GPCRs is an important process that allows …