A large body of evidence has demonstrated that exposure to childhood maltreatment at any
stage of development can have long-lasting consequences. It is associated with a marked …

Maltreatment-related childhood adversity is the leading preventable risk factor for mental
illness and substance abuse. Although the association between maltreatment and …

Background Childhood maltreatment is the most important preventable cause of
psychopathology accounting for about 45% of the population attributable risk for childhood …

In the past two decades, much evidence has accumulated unequivocally demonstrating that
child abuse and neglect is associated with a marked increase in risk for major psychiatric …

Investigating the developmental sequelae of early life stress has provided researchers the
opportunity to examine adaptive responses to extreme environments. A large body of work …

Purpose Although there is considerable evidence that adversities in childhood such as
social deprivation, sexual abuse, separation from parents, neglect and exposure to deviant …

Early childhood deprivation is associated with higher rates of neurodevelopmental and
mental disorders in adulthood. The impact of childhood deprivation on the adult brain and …

Objective Childhood maltreatment acts as a severe stressor that produces a cascade of
physiological and neurobiological changes that lead to enduring alterations in brain …

Evidence that childhood adversities are risk factors for psychosis has accumulated rapidly.
Research into the mechanisms underlying these relationships has focused, productively, on …

There is a growing body of research focused on the relationship between childhood trauma
and the risk of developing psychosis. Numerous studies, including many large-scale …