Copper metabolism in cell death and autophagy

Q Xue, R Kang, DJ Klionsky, D Tang, J Liu, X Chen - Autophagy, 2023 - Taylor & Francis
Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …

Autophagy in major human diseases

DJ Klionsky, G Petroni, RK Amaravadi… - The EMBO …, 2021 - embopress.org
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Copper-dependent autophagic degradation of GPX4 drives ferroptosis

Q Xue, D Yan, X Chen, X Li, R Kang, DJ Klionsky… - Autophagy, 2023 - Taylor & Francis
Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted
lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays …

GPX4 in cell death, autophagy, and disease

Y Xie, R Kang, DJ Klionsky, D Tang - Autophagy, 2023 - Taylor & Francis
ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …

Autophagy in metabolic disease and ageing

M Kitada, D Koya - Nature Reviews Endocrinology, 2021 - nature.com
Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …

Programmed cell death tunes tumor immunity

J Liu, M Hong, Y Li, D Chen, Y Wu, Y Hu - Frontiers in immunology, 2022 - frontiersin.org
The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

Organelle-specific regulation of ferroptosis

X Chen, R Kang, G Kroemer, D Tang - Cell Death & Differentiation, 2021 - nature.com
Ferroptosis, a cell death modality characterized by iron-dependent lipid peroxidation, is
involved in the development of multiple pathological conditions, including ischemic tissue …

Interplay between NLRP3 inflammasome and autophagy

M Biasizzo, N Kopitar-Jerala - Frontiers in Immunology, 2020 - frontiersin.org
The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …

Mechanisms of selective autophagy

T Lamark, T Johansen - Annual review of cell and …, 2021 - annualreviews.org
Selective autophagy is the lysosomal degradation of specific intracellular components
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …

Mechanisms governing autophagosome biogenesis

H Nakatogawa - Nature reviews Molecular cell biology, 2020 - nature.com
Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …