Thiazole ring—A biologically active scaffold
A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …
applications. Its derivatives have a wide range of biological activities such as antioxidant …
Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?
CB Mishra, M Tiwari, CT Supuran - Medicinal Research …, 2020 - Wiley Online Library
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are widely distributed metalloenzymes in
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …
Synthesis and pharmacological properties of chalcones: a review
SL Gaonkar, UN Vignesh - Research on chemical intermediates, 2017 - Springer
Chalcones and their analogs have been an area of great interest in recent years. Numerous
research papers have been published, and chalcones continue to show promise for new …
research papers have been published, and chalcones continue to show promise for new …
Synthesis, characterization, anticancer, antimicrobial and carbonic anhydrase inhibition profiles of novel (3aR, 4S, 7R, 7aS)-2-(4-((E)-3-(3-aryl) acryloyl) phenyl)-3a, 4 …
In the present study, a series of new hybrid compounds containing chalcone and
methanoisoindole units 7a-n ((3aR, 4S, 7R, 7aS)-2-(4-((E)-3-(3-aryl) acryloyl) phenyl)-3a, 4 …
methanoisoindole units 7a-n ((3aR, 4S, 7R, 7aS)-2-(4-((E)-3-(3-aryl) acryloyl) phenyl)-3a, 4 …
Novel adamantane-pyrazole and hydrazone hybridized: Design, synthesis, cytotoxic evaluation, SAR study and molecular docking simulation as carbonic anhydrase …
MMS Wassel, A Ragab, GAME Ali, ABM Mehany… - Journal of Molecular …, 2021 - Elsevier
A series of pyrazole derivatives 4, 5, 6, 12, 13, 14 as well as hydrazone derivatives 7, 10, 11
were synthesized starting from adamantane-1-carbohydrazide as the bioactive core. All …
were synthesized starting from adamantane-1-carbohydrazide as the bioactive core. All …
Synthesis, spectroscopic (FT-IR, FT-Raman, NMR), reactivity (ELF, LOL and Fukui) and docking studies on 3-(2‑hydroxy-3‑methoxy-phenyl)-1-(3-nitro-phenyl) …
The present article encloses synthesis and characterizations of 3-(2‑hydroxy-3‑methoxy-
phenyl)-1-(3-nitro-phenyl)-propenoneby several experimental techniques such as FT-IR, FT …
phenyl)-1-(3-nitro-phenyl)-propenoneby several experimental techniques such as FT-IR, FT …
Recent advances in biological active sulfonamide based hybrid compounds Part A: Two-component sulfonamide hybrids
Sulfonamides constitute an important class of drugs, with many types of pharmacological
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …
Design, synthesis, characterization of peripherally tetra-pyridine-triazole-substituted phthalocyanines and their inhibitory effects on cholinesterases (AChE/BChE) and …
In this study, phthalocyanine precursors (5 and 9) and 1, 2, 3-triazole-substituted metal-free
and metallo phthalocyanines (9a–c) were designed and synthesized for the first time and …
and metallo phthalocyanines (9a–c) were designed and synthesized for the first time and …
Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1, 2, 3-triazole chalcone hybrids
Sulfonamide is one of the most promising classes of classical carbonic anhydrase (CA, EC
4.2. 1.1) inhibitors. A novel series of indolylchalcones incorporating benzenesulfonamide-1 …
4.2. 1.1) inhibitors. A novel series of indolylchalcones incorporating benzenesulfonamide-1 …
Synthesis, structural characterizations, and quantum chemical investigations on 1-(3-methoxy-phenyl)-3-naphthalen-1-yl-propenone
In the present study, 1-(3-methoxy-phenyl)-3-naphthalen-1-yl-propenone (MPNP) is
synthesized and characterized by several experimental techniques such as Fourier …
synthesized and characterized by several experimental techniques such as Fourier …