Extracellular vesicles in cancer drug resistance: roles, mechanisms, and implications

Q Yang, J Xu, J Gu, H Shi, J Zhang, J Zhang… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are cell‐derived nanosized vesicles that mediate cell‐to‐cell
communication via transporting bioactive molecules and thus are critically involved in …

Molecular mechanisms for tumour resistance to chemotherapy

ST Pan, ZL Li, ZX He, JX Qiu… - Clinical and Experimental …, 2016 - Wiley Online Library
Chemotherapy is one of the prevailing methods used to treat malignant tumours, but the
outcome and prognosis of tumour patients are not optimistic. Cancer cells gradually …

The TRAIL in the treatment of human cancer: an update on clinical trials

M Snajdauf, K Havlova, J Vachtenheim Jr… - Frontiers in molecular …, 2021 - frontiersin.org
TRAIL (tumor-necrosis factor related apoptosis-inducing ligand, CD253) and its death
receptors TRAIL-R1 and TRAIL-R2 selectively trigger the apoptotic cell death in tumor cells …

Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)

R Rathore, JE McCallum, E Varghese, AM Florea… - Apoptosis, 2017 - Springer
Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control
of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within …

Onto better TRAILs for cancer treatment

D de Miguel, J Lemke, A Anel, H Walczak… - Cell Death & …, 2016 - nature.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …

The role of TRAIL in apoptosis and immunosurveillance in cancer

JM Pimentel, JY Zhou, GS Wu - Cancers, 2023 - mdpi.com
Simple Summary Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)
plays an important role in apoptosis and tumor immunosurveillance. Because TRAIL …

Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

R Qin, FM You, Q Zhao, X Xie, C Peng, G Zhan… - Journal of hematology & …, 2022 - Springer
Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …

The multifaceted role of TRAIL signaling in cancer and immunity

L Cardoso Alves, N Corazza, O Micheau… - The FEBS …, 2021 - Wiley Online Library
Tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) is a member of the
TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells …

The bioengineered and multifunctional nanoparticles in pancreatic cancer therapy: Bioresponisive nanostructures, phototherapy and targeted drug delivery

MJ Saadh, H Baher, Y Li, JL Arias-Gonzáles… - Environmental …, 2023 - Elsevier
The multidisciplinary approaches in treatment of cancer appear to be essential in term of
bringing benefits of several disciplines and their coordination in tumor elimination. Because …

TRAIL delivery by MSC-derived extracellular vesicles is an effective anticancer therapy

ZQ Yuan, KK Kolluri, KHC Gowers… - Journal of extracellular …, 2017 - Taylor & Francis
Extracellular vesicles (EVs) are lipid membrane-enclosed nanoparticles released by cells.
They mediate intercellular communication by transferring biological molecules and therefore …