Metabolite identification represents a major challenge, and opportunity, for biochemistry.
The collective characterization and quantification of metabolites in living organisms, with its …

The systematic and quantitative molecular analysis of mutant organisms that has been
pioneered by studies on mutant metabolomes and transcriptomes holds great promise for …

Mass spectrometry is a powerful technology for the analysis of large numbers of
endogenous proteins,. However, the analytical challenges associated with comprehensive …

Systematic and quantitative analysis of protein phosphorylation is revealing dynamic
regulatory networks underlying cellular responses to environmental cues. However …

High-throughput technologies for DNA sequencing and for analyses of transcriptomes,
proteomes and metabolomes have provided the foundations for deciphering the structure …

High-resolution mass spectrometry (MS)-based proteomics has progressed tremendously
over the years. For model organisms like yeast, we can now quantify complete proteomes in …

The development of mass spectrometry (MS)-based methodologies for high-throughput
protein identification has generated a concomitant need for protein quantification. Numerous …

Protein biomarker discovery produces lengthy lists of candidates that must subsequently be
verified in blood or other accessible biofluids. Use of targeted mass spectrometry (MS) to …

Previously, large-scale proteomics was possible only for organisms whose genomes were
sequenced, meaning the most common model organisms. The use of next-generation …

Given the rapid developments in mass spectrometry (MS) in terms of sensitivity, mass
accuracy, and throughput, some have suggested that two-dimensional gel electrophoresis …